P072 Melanocortin MC3 and MC5 receptors expression is different according to colonic disease activity in Crohn’s Disease and Ulcerative Colitis biopsies: results from an immunohistochemical observational study

Abstract Background MC3-R and MC5-R receptors belong to the complex melanocortin system, which has shown a strong immunomodulatory activity in several studies. Data on role of these relation inflammatory bowel disease are still missing not fully elucidated. In this observational study we wanted evaluate expression profile them colonic mucosa Crohn’s Disease Ulcerative Colitis patients both tracts directly affected by spared. Methods We conducted biopsies with histological diagnosis immunohistochemical analyses order assess degree MC5-R. Biopsies were performed traits macroscopic signs inflammation macroscopically normal whether two was different activity. Results ulcerative colitis diseased (CD: +7.7 fold vs mucosa, P < 0.01; UC: +5.6 0.01) +5.5 +8.1 significantly increased compared healthy mucosa. Conclusion expressed colon Colitis. addition, is higher most providing potential use diseases pharmacology.